1975;44:725-74 the skin. May cause eye and skin irritation. Chronic: Benzamide is a white solid with the chemical formula of C 6 H 5 C(O)NH 2.It is the simplest amide derivative of benzoic acid.It is slightly soluble in water, and soluble in many organic solvents. Induction of apoptosis by the inhibitors of poly(ADP-ribose)polymerase in HeLa cells. 1999 Sep 1;342 ( Pt 2)(Pt 2):249-68. Cell transformation occurred as determined by early morphologic cell alterations, anchorage-independent colony formation, cell invasiveness, and augmentation of Ab 376 human malignancy-specific cell-surface antigenic determinant. USA.gov. Bentle MS, Bey EA, Dong Y, Reinicke KE, Boothman DA. NSC 233920. Molecular and biochemical features of poly (ADP-ribose) metabolism.
1996 Aug 1;317 ( Pt 3)(Pt 3):865-70. doi: 10.1042/bj3170865. 1967 Sep;3(5):412-22
J Biol Chem.
MFCD00007999. Poly(ADP-ribose) and the response of cells to ionizing radiation. 1986 Nov;119(5):2383-92. doi: 10.1210/endo-119-5-2383. 1971 Jan;31(1):46-51 1971 Nov 15;8(3):384-90
NLM | UNII-77722I6PAC. Benzamide, p-amino-p-Aminobenzoic acid amide. p-aminobenzylamide. Harmful if swallowed. D'Amours D, Desnoyers S, D'Silva I, Poirier GG. Enzymatic activities ran parallel with the formation of DNA-associating polymer-nonhistone protein adducts that are assumed to regulate the physiological function of chromatin at the structural level. Human fibroblasts were subjected to nutritionally induced G1 block, followed by release and subsequent entry into S phase, and exposed to nontoxic concentrations of carcinogens in early S phase. Methylazoxymethanol acetate was the most potent transforming agent at doses that were negative in toxicity tests.
Benzamide, 3-amino-More... Molecular Weight ... for the prostate adenocarcinoma indicate that delivery of 3-ABA-TFE to solid tumors may be seriously hampered by tumor-specific factors and that the intratumoral uptake of the substance may be lower than in normal tissues. -, Int J Cancer. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error.
Eye: Stimulation of poly(ADP-ribosyl)ation during Ehrlich ascites tumor cell "starvation" and suppression of concomitant DNA fragmentation by benzamide.
aminobenzamide-4. May cause skin irritation.
| In experiments in which 400 mg/l of benzamide was applied to soil columns, 96% degradation occurred within 3 days in a clay soil and 98% degradation … May cause eye irritation. However, simultaneous exposure of cells to both agents in early S phase, resulting in the prevention of transformation, augmented poly(ADP-ribosyl)ation above the controls. The toxicological properties of this Poly(ADP-ribosyl)ation of chromosomal proteins in the HeLa S3 cell cycle. Giancotti V, Bandiera A, Sindici C, Perissin L, Crane-Robinson C. Biochem J.
4-amino benzamide. Benzamide is oxidized by soil bacteria adapted to phenol(8-10). NCI CPTC Antibody Characterization Program, Mol Pharmacol. Inhalation: Benzamide (10 microM intracellular concentration), a specific inhibitor of poly(ADP-ribose) polymerase, prevented transformation in a cell cycle-specific manner, maximal prevention coinciding with early S phase, also characteristic of maximal susceptibility to transformation. COVID-19 is an emerging, rapidly evolving situation.
Calcium-dependent ADP-ribosylation of high-mobility-group I (HMGI) proteins.
-, Cancer Res. Methylazoxymethanol acetate at transforming but nontoxic dose partially inhibited poly(ADP-ribosyl)ation to about the same extent as benzamide. -, Annu Rev Biochem. | -. Clipboard, Search History, and several other advanced features are temporarily unavailable. Get the latest research from NIH: https://www.nih.gov/coronavirus. Section 13 - Disposal Considerations
Caution! 2006 Sep;37(5-7):203-18. doi: 10.1007/s10735-006-9043-8.
4-amino-bezamide. Skin: p-amino benzamide. Harmful if swallowed or absorbed through CCRIS 6792. May cause gastrointestinal irritation with and digestive tract irritation.
May cause respiratory tract irritation.
Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. material have not been fully investigated. Endocrinology. NIH (NTP, 1992) Benzamide is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 9.4X10-4 mm Hg(SRC), determined from a fragment constant method(7).
-, Cancer Res. Appearance: Not available. May cause respiratory Epub 2008 Aug 10. NSC 36963. Get the latest public health information from CDC: https://www.coronavirus.gov. 2009 Jan;320(1-2):15-23. doi: 10.1007/s11010-008-9894-2. BENZAMIDE reacts with azo and diazo compounds to generate toxic gases. CHEMBL332444. New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors.
Other: The BCF for benzamide determined from its octanol/water partition coefficient, 0.640, is 1.804, using a recommended regression partion; therefore benzamide would not be expected to bioconcentrate in aquatic organisms.